Cardiovascular, Metabolic and Renal T‐cell Profile of Obese C57Bl6 mice: Role of Renal Nerves

• DOI: 10.1096/fasebj.29.1_supplement.667.1
• Publication Date: 2021-06-21T18:36:46Z
• Authors: Ninitha Asirvatha...; Jessica Fiege; Ruijun Han; Jason Foss; Alessandro Bartol...; Maria Razzoli; Brandon Burbach; Yoji Shimizu; John Osborn
• Keywords: Carbohydrate Metabolism; Sympathetic nervous system

Hypertension (HTN) is a global epidemic and often occurs in concurrence with obesity diabetes (i.e. metabolic syndrome). Recent clinical trials suggest that renal denervation (RDNX) decreases blood pressure (BP) improves glucose metabolism drug resistant hypertensive patients. Using murine model we tested the hypothesis associated inflammation secondary to T cell infiltration, which activates sensory nerves increases sympathetic activity. 8‐week old C57Bl6 mice were fed either low fat diet (LFD; 10 KCal% fat) or high (HFD; 45 for weeks. Two parallel protocols conducted. In protocol, body weight, food intake, composition fasting measured. cardiovascular implanted radiotelemeters measurement of BP. Mice on HFD exhibited increased splenic cells indicating peripheral inflammation, syndrome phenotype including mass, HTN hyperglycemia compared LFD. RDNX but not Sham surgery after 12 weeks normalized BP (116 ± 4 sham vs. 97 6 mmHg mice). had no effect LFD mice. Finally, as determined by tolerance test. These results play role induced do contribute impaired this model. Future data analysis will test drives afferent activity obesity‐induced HTN. Supported RO1HL116476.