A non‐human primate model for Yersinia pestis infection: metabolomic analysis pilot study

• DOI: 10.1096/fasebj.29.1_supplement.718.6
• Publication Date: 2021-06-21T16:54:04Z
• Authors: Aarti Gautam; Stacy Miller; Allison Hoke; Rasha Hammamieh; Marti Jett
• Keywords: Yersinia pestis; Infectious dose; plague

Yersinia pestis , the etiological agent of plague, is a potential biothreat agent. Upon inhalation, Gram‐negative bacterium causes pneumonic rapidly progressing, severe lung infection that usually fatal. Only limited work using metabolite profiles to study progression disease has been done, and exact mechanisms facilitate are not well‐characterized. In this study, African Green monkeys were exposed aerosolized highly virulent Y. CO92 metabolomic profiling plasma samples was conducted. Comparison control counterparts states at earlier time points (6 hours 18 hours) versus later (24 onwards) showed mainly two‐fold higher increases in levels certain polyunsaturated fatty acids, long chain acids metabolites from acid metabolism pathway. Significant alterations related early inflammation oxidative stress, increased energy demands host, renal dysfunction revealed. The metabolomics have provide more thorough understanding pathogenesis, which may assist future treatment disease. grant # TMTI0029_09_WR_T Department Defense Chemical Biological program through Threat Reduction Agency acknowledged. DISCLAIMER “Research conducted compliance with Animal Welfare Act all other Federal requirements. views expressed those authors do constitute endorsement by U.S. Army.”