Impact of maternal infection and breast inflammation on infant growth in Guatemala

• DOI: 10.1096/fasebj.30.1_supplement.45.6
• Publication Date: 2023-11-26T16:52:35Z
• Authors: Hilary M Wren; Andreanne L Leblanc; Chen Li; Noel W Solomons; Marilyn E Scott; Kristine G Koski
• Keywords: Subclinical infection

Background It is well known that certain maternal infections impair infant growth. Less clear whether subclinical asymptomatic breast inflammation during the first six months of lactation will also retard During mastitis, a common inflammatory condition lactating breast, tight epithelial junctions become “leaky” allowing for movement sodium and potassium, pro‐inflammatory cytokines, growth factors into milk via paracellular pathway. The objectives this longitudinal study were to: (1) to explore consequences infection on weight‐for‐age (WAZ), length‐for‐age (LAZ) head‐circumference‐for‐age (HCZ) at two stages lactation; (2) investigate relative contribution cytokines anthropometry. Methods Breast samples collected from cohort Mam ‐Mayan mothers early (0–6 wks, n=134) established (4–6 mo, n=120). Inductively Coupled Plasma Mass Spectrometry measured Na K. Luminex (IL‐1, IL‐6, IL‐8, TNF‐a) (EGF, VEGF). Analysis presence urine leukocytes direct smear stool non‐pathogenic protozoa ( Blastocystis hominis, Entamoeba coli , Iodamoeba butschli Endolimax nana ) measured. Independent variables leakiness (Na/K ratio), inflammation, in explored separate multiple linear regression models LAZ, WAZ HCZ lactation. Results leakiness, as by higher Na/K ratio, was positively correlated with all but lactation, only IL‐6 ratio. In LAZ associated height leukocytes. weight negatively ratio hominis. hominis cytokine milk. EGF TFN‐a. Conclusion Our integrative approach shows contribute poor However, contrast our expectation would promote growth, we observed opposite be true which suggests more complex interrelationship among infection, than previously understood. Support or Funding Information McGill University, School Dietetics Human Nutrition GREAT award;McGill Institute Parasitology Centre Host‐Parasite Interaction Bridging Funds