Sleep Apnea Worsens Muscle Vasoconstriction During Central and Peripheral Chemoreceptors Stimulation in Patients with Systolic Heart Failure

• DOI: 10.1096/fasebj.30.1_supplement.755.6
• Publication Date: 2023-11-26T16:48:44Z
• Authors: Denise M L Lobo; Patricia F Trevizan; Edgar Toschi‐Dias; Patricia A Oliveira; Rafael B Piveta; Charles Mady; Edimar A Bocchi; Dirceu R Almeida; Geraldo Lorenzi‐F...; Holly R Middlekauff; Carlos E Negrão
• Keywords: Microneurography; Hypoxia; Central sleep apnea

We tested the hypothesis that muscle vasoconstriction in response to hypercapnia and hypoxia would be more pronounced patients with chronic heart failure (CHF) sleep apnea than CHF alone. Ninety consecutive patients, Functional Class II‐III NYHA, LVEF≤40% were selected study. Forty‐two who fulfilled all inclusion criteria enrolled study: No Sleep Disordered Breathing (NoSDB, n=13, 47±3y), Obstructive Apnea (OSA, n=22, 57±1y) Central (CSA, n=07, 53±3y). was characterized by apnea‐hypopnea index≥15 events/hour (polysomnography). (7%CO 2 93%O ) peripheral (10%O 90%N , CO titrated) chemoreceptors stimulated for 3 min. Muscle sympathetic nervous activity (MSNA) evaluated microneurography technique, forearm (FBF) calf (CBF) blood flow venous occlusion plethysmography, pressure beat‐to‐beat noninvasive technique. Baseline MSNA, FBF, vascular conductance (FVC), CBF, (CVC) similar among groups. FBF (hypercapnia: P =0.001; hypoxia: =<0.001) CBF =<0.001; =0.002) responses significantly lower OSA CSA groups compared NoSDB group. FVC CVC =0.001) also MSNA not different studied =0.12; =0.17). Patients obstructive or central have severe during The similarities suggest these are associated endothelial dysfunction. Support Funding Information CNPq #140265/2013‐9 FAPESP #2010/50048‐1