Effects of Dried Plum and Chokeberry on D‐galactose‐induced Aging Model

• DOI: 10.1096/fasebj.31.1_supplement.645.15
• Publication Date: 2023-11-26T17:18:44Z
• Authors: Oeuk Jeong; Heesoo Jeong; Yanan Liu; Hyun‐Sook Kim

Dietary polyphenol has been shown to reduce oxidative and inflammatory reaction in animal models. Dried plum has been reported to be associated with bone metabolism and only few studies mentioned about antioxidative activities of dried plum especially focusing on aging. In this study, we investigated the effects of dried plum and chokeberry on aging markers and antioxidant activities with D‐galactose‐induced aging mouse model. After adaptation period, Balb/c mice were randomly divided into four groups(n=7 for each group): control group(C), D‐galactose‐induced aging group(D), D‐galactose‐induced aging with 10% dried plum group(P), D‐galactose‐induced aging with 1% chokeberry group(CH). All groups except for control group were injected with D‐galactose intraperitoneally for 8 weeks and control group was treated with saline as a substitute. After 8 weeks of treatment, the food intake and body weight gain showed no significant differences among all groups. There was a significant increase in serum malondialdehyde(MDA), liver MDA, and advanced glycation end products(AGE) levels in D group compared with control group(p<0.05). P and CH groups showed higher protein expression of KEAP1 in liver than D group, whereas the protein expression of SOD2 was showed significant increase in P and CH groups relative to D group(p<0.05). Enhancements in the protein expression of KEAP1 and SOD2 in P and CH groups were comparable to the result of control group(p<0.05). These results indicate that dried plum and chokeberry can improve some aging markers in D‐galactose‐induced aging mouse model.