Soy Consumption and the Risk of Prostate Cancer in Men: An Updated Systematic Review and Meta‐analysis

• DOI: 10.1096/fasebj.31.1_supplement.790.35
• Publication Date: 2023-11-26T17:55:47Z
• Authors: Catherine C Apple...; Joe L Rowles; Katherine M Ranard; Sookyoung Jeon; John W Erdman
• Keywords: 2. Zero hunger; 3. Good health

Background Prostate cancer (PCa) is the third most commonly diagnosed and sixth common cause of cancer‐related deaths in United States. Worldwide, PCa second fifth leading deaths. incidence higher more developed countries, with Australia/New Zealand North America having highest rates, while rates remain lowest Asian countries. The lower populations has been associated consumption soy foods. Soy under intensifying scrutiny recent years for its potential role prevention hormone‐driven cancers. purpose this study to provide an updated systematic review meta‐analysis focused on association foods risk men. Methods A determine influence food men currently underway. Eligible studies were published before October 10, 2016 identified from PubMed, Web Science, Cochrane Library. Articles using following key words their variants: prostate cancer, neoplasm, soy, soymilk, milk, isoflavone, bean curd, tofu, protein, daidzein, genistein. For have included meta‐analysis, they must met criteria: (a) evaluated between by randomized control trials cohort, cross‐sectional, retrospective, prospective, or case‐control studies; (b) methodology was documented replicable detail; (c) relationship risk; (d) relative ratio 95% confidence intervals exposure categories; (e) written English; (f) peer‐reviewed publications theses. We will utilize a Newcastle‐Ottawa Scale order assess quality data. Additionally, data articles utilized comparisons consumption, dose‐response relationships, publication bias. From these comparisons, we estimate pooled ratios (RR) (CI) random fixed effects models. Results After screening literature, total 3,309 identified. Eight hundred thirty‐six immediately removed as duplicates. Of 2,473 remaining articles, 2,444 through abstract process, 29 full‐text review. reviewing full text, 22 inclusion criteria be analyzed meta‐analysis. Significance Data gleaned result effect PCa, providing support nonsupport beneficial increased risk.