Can Bone Regulating Hormones and Nutrients Characterize the Metabolically Healthy Obese Phenotype?

• DOI: 10.1096/fasebj.31.1_supplement.797.9
• Publication Date: 2023-11-26T17:55:47Z
• Authors: May Cheung; Kendra Becker; Diamond Samantha; Duszak Rita; McNamee Lisa; Christine Wojciec...; Suresh Aditi; Aljahdali Abeer; Chenuit Margaret‐...; Deeptha Sukumar
• Keywords: Bone remodeling

The term Metabolically healthy obese (MHO) phenotype has been used to describe those who present with a benign metabolic profile despite excess adiposity. These individuals are but either completely free of abnormalities or have less than three components syndrome. Previous studies suggest that bone regulating hormones and nutrients, such as parathyroid hormone (PTH), 25‐hydroxyvitamin D (25OHD), estrogen, osteocalcin, vitamin D, calcium magnesium (Mg) influence overall energy metabolism. In this study, we aim determine whether nutrients can help characterize the MHO phenotype. We hypothesize adequate Mg status, higher serum 25OHD lower PTH concentrations variable could be included in characterization MHP A total 27 overweight adults (BMI 25–40 kg/m 2 ) were recruited. Measurements obtained for ionized Mg, 25OHD, PTH, body fat percentage, trunk mass, blood pressure, glycemic indices, lipid profile, pro‐inflammatory cytokines order factors differentiating vs metabolically unhealthy (MUO) sample. Based on presence abnormalities, participants classified (n=13) MUO (n=14). Results showed no significant difference mean age between group (Mean : 32.6 ± 9.2 yr). As expected, insulin diastolic BP compared (p < 0.04). addition, triglyceride c‐reactive protein did not differ groups. Dietary intake tended (270.4 181.7 mg/day) (195.4 88.9 mg/day). Ionized concentration was significantly 0.04) group. Serum groups, while 0.02) (61.8 25.9 pg/mL) (40.2 11.5 pg/mL). osteocalcin c‐telopeptide collagen also summary had better levels turnover markers, some which shown regulate Early recognition alterations these potential target intervention prevention population. Support Funding Information American Heart Association‐ Scientist Development Grant‐ 16SDG27050002 Deeptha Sukumar