Synthesis of potential AAC(6′)‐Ib inhibitors to combat bacterial resistance to aminoglycoside antibiotics

• DOI: 10.1096/fasebj.31.1_supplement.939.10
• Publication Date: 2023-11-26T17:29:50Z
• Authors: Miranda Simes; Kristin Jansen Labby; Kathryn Johnson

One of the greatest threats to human health is rise antibiotic resistance in pathogenic bacteria, and failure treatment becoming far more common. Aminoglycosides, a family antibiotics, are too often being rendered ineffective by bacterial aminoglycoside modifying enzymes. Of various types enzymes, most common clinical isolates AAC(6′)‐Ib enzyme. In order combat modification enzyme, previous work has screened potential small molecule inhibitors identified lead inhibitor. We working synthesize test potency this inhibitor on Recently, synthesis purification were optimized. Currently, underway library derivatives also which will aid determining structure‐activity relationships between Support or Funding Information Beloit College Biomedical Research Scholars Program provided funding for work.