Reduction of amyloid load and cerebral damage in transgenic mouse model of Alzheimer's disease by treatment with a β‐sheet breaker peptide

• DOI: 10.1096/fj.01-0841fje
• Publication Date: 2002-07-26T23:04:26Z
• Authors: Bruno Permanne; Céline Adessi; Gabriela P. Saborio; Santiago Fraga; Marie‐José Frossard; Jo Van Dorpe; Ilse Dewachter; William A. Banks; Fred Van Leuven; Claudio Soto
• Keywords: Amyloid (mycology); Pathogenesis; Amyloid beta

AIMSDeposition of cerebral amyloid plaques is a hallmark feature Alzheimer's disease (AD) and reduction load widely regarded as the most promising therapy for disease.We investigated ability five-residue ␤-sheet breaker peptide (iA␤5p) with improved pharmacological properties to reduce deposition damage in vivo using two different transgenic mice models AD.