Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

• DOI: 10.1096/fj.201700968r
• Publication Date: 2018-05-11T17:31:54Z
• Authors: Sara Mijwel; Daniele A. Cardinale; Jessica Norrbom; Mark Chapman; Niklas Ivarsson; Yvonne Wengström; Carl Johan Sundberg; Helene Rundqvist
• Keywords: High-Intensity Interval Training; Interval training

Exercise has been suggested to ameliorate the detrimental effects of chemotherapy on skeletal muscle. The aim this study was compare different exercise regimens with usual care muscle morphology and mitochondrial markers in patients being treated for breast cancer. Specifically, we compared moderate-intensity aerobic training combined high-intensity interval (AT-HIIT) resistance (RT-HIIT) (UC). Resting biopsies were obtained pre- postintervention from 23 randomly selected women OptiTrain cancer trial who underwent RT-HIIT, AT-HIIT, or UC 16 wk. Over intervention, citrate synthase activity, fiber cross-sectional area, capillaries per fiber, myosin heavy chain isoform type I reduced UC, whereas RT-HIIT AT-HIIT able counteract these declines. promoted up-regulation electron transport protein levels vs. UC. favored satellite cell count AT-HIIT. There a significant association between change activity self-reported fatigue. RT- HIIT maintained improved function declines found group, indicating sustained trainability addition preservation structural metabolic characteristics during chemotherapy. These findings highlight importance supervised programs chemotherapy.—Mijwel, S., Cardinale, D. A., Norrbom, J., Chapman, M., Ivarsson, N., Wengstrom, Y., Sundberg, C. Rundqvist, H. preserves capillarization, content FASEB J. 32, 5495–5505 ((2018). www.fasebj.org