Competitive apnea and its effect on the human brain: focus on the redox regulation of blood‐brain barrier permeability and neuronal‐parenchymal integrity

• DOI: 10.1096/fj.201701031r
• Publication Date: 2017-11-30T17:05:12Z
• Authors: Anthony R. Bain; Philip N. Ainslie; Ryan L. Hoiland; Otto F. Barak; Ivan Drvis; Mike Stembridge; Douglas M. MacLeod; Jane McEneny; Benjamin S. Stacey; Eduoard Tuaillon; Nicola Marchi; Alexis Fayd'Herbe...; Zeljko Dujic; David B. MacLeod; Damian M. Bailey
• Keywords: Parenchyma

Static apnea provides a unique model that combines transient hypertension, hypercapnia, and severe hypoxemia. With durations exceeding 5 min, the purpose of present study was to determine how affects cerebral free-radical formation corresponding implications for brain structure function. Measurements were obtained before following maximal in 14 divers with transcerebral exchange kinetics, measured as product global blood flow (duplex ultrasound) radial arterial internal jugular venous concentration differences ( a-v