Long noncoding RNASNHG1promotes non‐small cell lung cancer progression by up‐regulatingMTDH viasponging miR‐145–5p

• DOI: 10.1096/fj.201701237rr
• Publication Date: 2018-02-21T18:36:14Z
• Authors: Qingchun Lu; Shan Shan; Yanyan Li; Dongyi Zhu; Wenjing Jin; Tao Ren
• Keywords: Small nucleolar RNA

Long noncoding RNAs participate in the progression and initiation of non-small cell lung cancer (NSCLC), although mechanism remains unknown. The lncRNA identified as small nucleolar RNA host gene 1 (SNHG1) is a novel that increased multiple human cancers; however, regulatory requires further investigation. In this study, we discovered SNHG1 was markedly up-regulated NSCLC tissues cells silencing decreased tumor volumes. Moreover, explored its found directly bound to microRNA (miRNA)-145–5p, isolating miR-145–5p from target MTDH. Inhibition suppressed viability, proliferation, migration, invasion vitro, but effect rescued by inhibition. These results demonstrate contributes modulating miR-145–5p/MTDH axis, it could potentially be therapeutic well diagnostic marker.—Lu, Q., Shan, S., Li, Y., Zhu, D., Jin, W., Ren, T. promotes up-regulating MTDH via sponging miR-145-5p. FASEB J. 32, 3957–3967 (2018). www.fasebj.org