Reciprocal transrepression between FOXF2 and FOXQ1 controls basal‐like breast cancer aggressiveness

• DOI: 10.1096/fj.201801916r
• Publication Date: 2019-02-26T23:07:22Z
• Authors: Li‐Juan Kang; Zi‐Han Yu; Jun Cai; Rui He; Jun‐Tao Lu; Chen Hou; Qing‐Shan Wang; Xiao‐Qing Li; Rui Zhang; Yu‐Mei Feng
• Keywords: Corepressor

FOXF2 and FOXQ1, forkhead box transcription factor superfamily members, are encoded by neighboring genes located on human chromosome 6p25.3 play opposite roles in epithelial-mesenchymal transition (EMT) metastasis basal-like breast cancer (BLBC). However, the relationship between FOXQ1 remains unknown. Here, we found mutual transcriptional repression reciprocal negative feedback loop controlled EMT, aggressiveness, chemoresistance BLBC cells. We further demonstrated that recruited nuclear receptor corepressor 1 histone deacetylase 3 to promoter inhibit its cells, but did not exert such an effect FOXF2. Our findings reveal novel mechanisms underlying determination of aggressiveness transrepressive function a cell subtype-specific manner. Therefore, blocking vicious cycle abnormal induce differentiation restore tissue homeostasis is promising strategy for treatment aggressive BLBC.-Kang, L.-J., Yu, Z.-H., Cai, J., He, R., Lu, J.-T., Hou, C., Wang, Q.-S., Li, X.-Q., Zhang, Feng, Y.-M. Reciprocal transrepression controls aggressiveness.