Lunasin attenuates oxidant‐induced endothelial injury and inhibits atherosclerotic plaque progression in ApoE−/−mice by up‐regulating heme oxygenase‐1viaPI3K/Akt/Nrf2/ARE pathway

• DOI: 10.1096/fj.201802251r
• Publication Date: 2019-01-02T21:18:36Z
• Authors: Lili Gu; Pei Ye; Hengli Li; Yue Wang; Yaqiong Xu; Qinghua Tian; Gaoxin Lei; Cheng Zhao; Zhan Gao; Wenfeng Zhao; Shuhua Tan
• Keywords: Apolipoprotein E

Oxidative stress-induced vascular endothelial cell (VEC) injury is a major mechanism in the initiation and development of atherosclerosis. Lunasin, soybean-derived 43-aa peptide, has been previously shown to possess potent antioxidant anti-inflammatory activities other than its established anticancer activities. This study investigated effects lunasin on protecting VECs from oxidative damage inhibiting atherosclerotic plaque progression apolipoprotein E-deficient (ApoE