Short‐chain fatty acids and microbiota metabolites attenuate ghrelin receptor signaling

• DOI: 10.1096/fj.201901433r
• Publication Date: 2019-09-23T23:13:55Z
• Authors: Cristina Torres‐F...; Anna V. Golubeva; Alexander V. Zhdanov; Shauna Wallace; Silvia Arboleya; Dimitri B. Papkovsky; Sahar El Aidy; Paul Ross; Bernard L. Roy; Catherine Stanton; Timothy G. Dinan; John F. Cryan; Harriet Schellekens
• Keywords: Metabolome; Cell Signaling; Gut–brain axis

The gastrointestinal microbiota is emerging as a unique and inexhaustible source for metabolites with potential to modulate G-protein coupled receptors (GPCRs). ghrelin receptor [growth hormone secretagogue (GHSR)-1a] GPCR expressed throughout both the gut brain plays crucial role in maintaining energy balance, metabolism, central modulation of food intake, motivation, reward, mood. To date, few studies have investigated its signaling. Here we investigate ability short-chain fatty acids (SCFAs), lactate, different bacterial strains, including Bifidobacterium Lactobacillus genera, GHSR-1a We identify, what our knowledge first time, potent effect microbiota-derived on signaling significant consequences host metabolism physiology. show that SCFAs, supernatants are able attenuate ghrelin-mediated through GHSR-1a. suggest novel route communication between via Together, this highlights therapeutic exploration metabolome specific targeting key GPCRs, pleiotropic actions span CNS periphery.-Torres-Fuentes, C., Golubeva, A. V., Zhdanov, Wallace, S., Arboleya, Papkovsky, D. B., El Aidy, Ross, P., Roy, B. L., Stanton, Dinan, T. G., Cryan, J. F., Schellekens, H. Short-chain