CD82 controls CpG‐dependent TLR9 signaling

• DOI: 10.1096/fj.201901547r
• Publication Date: 2019-08-13T23:10:57Z
• Authors: Nida S. Khan; Daniel P. Lukason; Marianela Feliu; Rebecca A. Ward; Allison K. Lord; Jennifer L. Reedy; Zaida G. Ramirez‐...; Jenny M. Tam; Pia V. Kasperkovitz; Paige E. Negoro; Tammy D. Vyas; Shuying Xu; Melanie M. Brinkmann; idu Acharaya; Katerina Artavani...; Eva‐Maria Frickel; Christine E. Becker; Zeina Dagher; You‐Me Kim; Eicke Latz; Hidde L. Ploegh; Michael K. Mansour; Cindy K. Miranti; Stuart M. Levitz; Jatin M. Vyas
• Keywords: TLR9; Tetraspanin

The tetraspanin CD82 is a potent suppressor of tumor metastasis and regulates several processes including signal transduction, cell adhesion, motility, aggregation. However, the mechanisms by which participates in innate immunity are unknown. We report that key regulator TLR9 trafficking signaling. recognizes unmethylated cytosine-phosphate-guanine (CpG) motifs present viral, bacterial, fungal DNA. demonstrate associate macrophages, occurs endoplasmic reticulum (ER) post-ER. Moreover, essential for TLR9-dependent myddosome formation response to CpG stimulation. Finally, modulates NF-κB nuclear translocation, critical inflammatory cytokine production. To our knowledge, this first time has been implicated as TLR Collectively, study demonstrates specific signaling, may be cancer immunotherapy approaches coordinating immune pathogens.-Khan, N. S., Lukason, D. P., Feliu, M., Ward, R. A., Lord, A. K., Reedy, J. L., Ramirez-Ortiz, Z. G., Tam, Kasperkovitz, P. V., Negoro, E., Vyas, T. D., Xu, Brinkmann, M. Acharaya, Artavanis-Tsakonas, Frickel, E.-M., Becker, C. Dagher, Z., Kim, Y.-M., Latz, Ploegh, H. Mansour, Miranti, Levitz, S. controls CpG-dependent