Albumin protects the liver from tumor necrosis factor α‐induced immunopathology

• DOI: 10.1096/fj.202001615rrr
• Publication Date: 2021-01-26T08:37:20Z
• Authors: Marta Duran‐Güell; Roger Flores‐Costa; Mireia Casulleras; Cristina López‐Vi...; Esther Titos; Alba Díaz; José Alcaraz‐Quiles; Raquel Horrillo; Montserrat Costa; Javier Fernández; Vicente Arroyo; Joan Clària
• Keywords: Serum Albumin

Besides its oncotic power, albumin exerts pleiotropic actions, including binding, transport, and detoxification of endogenous exogenous molecules, antioxidant activity, modulation immune inflammatory responses. In particular, recent studies have demonstrated that reduces leukocyte cytokine production. Here, we investigated whether also has the ability to protect tissues from damaging actions these mediators. We circumscribed our investigation tumor necrosis factor (TNF) α, which exemplifies connection between immunity tissue injury. vivo experiments in analbuminemic mice showed exhibit a more pronounced response model TNFα-mediated liver injury induced by administration lipopolysaccharide (LPS) D-galactosamine (D-gal). A protective action against LPS/D-gal was observed during human humanized expressing genes for neonatal Fc receptor (hAlb+/+ /hFcRn+/+ ) with preestablished carbon tetrachloride (CCl4 )-induced early cirrhosis. The cytoprotective TNFα-induced were confirmed ex vivo, precision-cut slices, vitro, primary hepatocytes culture. Albumin independent scavenging properties reproduced recombinant expressed Oryza sativa. cytoprotection TNFα related inhibition lysosomal cathepsin B leakage accompanied reductions mitochondrial cytochrome c release caspase-3 activity. These data provide evidence addition reducing cytokines, molecule