p53 regulation by MDM2 contributes to self‐renewal and differentiation of basal stem cells in mouse and human airway epithelium

• DOI: 10.1096/fj.202100638r
• Publication Date: 2021-08-16T07:04:21Z
• Authors: Sergio Garrido‐Ji...; Juan Francisco Ba...; Selene Diaz‐Chamorro; Clara Maria Mateo...; Ignacio Rodriguez...; Francisca Lourdes...; Maria Jesus Lorenzo; Francisco Centeno; Angel Carlos Roman; Jose Maria Carvaj...
• Keywords: Basal (medicine)

Abstract Proper physiological function of mammalian airways requires the differentiation basal stem cells into secretory or multiciliated cells, among others. In addition, self‐renewal ability these is crucial for developing a quick response to toxic agents in order re‐establish epithelial barrier airways. Although missions are vital, little known about those mechanism controlling airway regeneration health and disease. p53 has been recently proposed as guardian homeostasis, promoting programs, antagonizing de‐differentiation program. Here, we exploit mouse human tracheal cell culture models study role MDM2‐p53 signaling epithelium. We show that protein regulation by MDM2 keep proper proliferation. Therefore, suggest MDM2/p53 interaction modulation potential target control epithelia without massively affecting epithelium integrity potential.