15‐epi‐lipoxin A5 promotes neutrophil exit from exudates for clearance by splenic macrophages

• DOI: 10.1096/fj.202400610r
• Publication Date: 2024-07-11T08:59:01Z
• Authors: Hong Yong Peh; Robert Nshimiyimana; Thayse R. Brüggemann; Melody G. Duvall; Julie Nijmeh; Charles N. Serhan; Bruce D. Levy
• Keywords: efferocytosis; Lipoxin

Specialized proresolving mediators (SPMs) promote local macrophage efferocytosis but excess leukocytes early in inflammation require additional leukocyte clearance mechanism for resolution. Here, neutrophil mechanisms from localized acute were investigated mouse dorsal air pouches. 15-HEPE (15-hydroxy-5Z,8Z,11Z,13E,17Z-eicosapentaenoic acid) levels increased the exudates. Activated human neutrophils converted to lipoxin A