Expert consensus report on lipid mediators: Role in resolution of inflammation and muscle preservation

• DOI: 10.1096/fj.202400619r
• Publication Date: 2024-05-28T14:55:15Z
• Authors: Charles N. Serhan; Magnus Bäck; Valerio Chiurchiù; Martin Hersberger; Bettina Mittendorfer; Philip C. Calder; Dan L. Waitzberg; Christian Stoppe; Stanislaw Klek; Robert G. Martindale
• Keywords: Lipid Oxidation; Mediator

Abstract This meeting report presents a consensus on the biological aspects of lipid emulsions in parenteral nutrition, emphasizing unanimous support for integration emulsions, particularly those containing fish oil, owing to their many potential benefits beyond caloric provision. Lipid have evolved from simple energy sources complex formulations designed improve safety profiles and offer therapeutic benefits. The highlights critical role omega‐3 polyunsaturated fatty acids (PUFAs), notably eicosapentaenoic acid (EPA) docosahexaenoic (DHA), found oil other marine oils, anti‐inflammatory properties, muscle mass preservation, as precursors specialized pro‐resolving mediators (SPMs). SPMs play significant immune modulation, tissue repair, active resolution inflammation without impairing host defense mechanisms. panel's agreement underscores importance incorporating within clinical practices facilitate recovery conditions like surgery, illness, or immobility, while cautioning against therapies that might disrupt natural processes. not only reaffirms specific components enhancing patient outcomes, but also suggests shift towards nutrition‐based strategies settings, advocating proactive evidence‐based use enriched with PUFAs. Furthermore, we should seek apply our knowledge concerning DHA, EPA, SPM derivatives, produce more informative randomized controlled trial protocols, thus allowing authoritative recommendations.