LncRNA‐Snhg3 regulates mouse hepatic glycogenesis under normal chow diet

• DOI: 10.1096/fj.202401064r
• Publication Date: 2024-08-12T12:24:29Z
• Authors: Xianghong Xie; Mingyue Gao; Heping Wang; Minglong Zhang; Wei Zhao; Chunmei Li; Weihong Zhang; Jiahui Yang; Yinliang Zhang; Enhui Chen; Yanfang Guo; Zeyu Guo; Ebenezeri Erasto ...; Xiaoman Wang; Yinghan Zhu; Yiting Wang; Xiaolu Li; Hong Yao; Li Yan; Fude Fang; Meixia Li; Aijun Qiao; Xiaojun Liu
• Keywords: Glycogenesis

Long noncoding RNAs (lncRNAs) are strongly associated with glucose homeostasis, but their roles remain largely unknown. In this study, the potential role of lncRNA-Snhg3 in metabolism was evaluated both vitro and vivo. Here, we found a positive relationship between Snhg3 hepatic glycogenesis. Glucose tolerance improved hepatocyte-specific knock-in (Snhg3-HKI) mice, while it worsened knockout (Snhg3-HKO) mice. Furthermore, glycogenesis had shown remarkable increase Snhg3-HKI mice reduction Snhg3-HKO respectively. Mechanistically, increased mRNA protein expression levels PPP1R3B through inducing chromatin remodeling promoting phosphorylation kinase B. Collectively, these results suggested that plays critical