Cuproptosis inhibits tumor progression and enhances cisplatin toxicity in ovarian cancer

• DOI: 10.1096/fj.202500047r
• Publication Date: 2025-03-23T16:10:19Z
• Authors: Qiaojian Zou; Yili Chen; Duo Liu; Qiqiao Du; Chunyu Zhang; Qiuwen Mai; Xiaojun Wang; Xiaoying Lin; Qianrun Chen; Mengxun Wei; Chudan Chi; Shuzhong Yao; Junxiu Liu

Abstract Cuproptosis is a novel form of regulated cell death triggered by copper ion and ionophore. While cuproptosis has been actively explored as potential target for cancer therapy, its role in ovarian (OC) still remains unclear. In this study, we demonstrate that inhibits OC proliferation, migration, invasion through FDX1 regulation suppresses tumor growth mouse model. We also confirm enhances sensitivity to cisplatin treatment both vivo vitro. Moreover, our findings reveal affects cholesterol biosynthesis cells, with playing crucial cytotoxic effect. Taken together, results elucidate the effect suggest it promising therapeutic strategy.