Multidrug-Resistant Tuberculosis Versus Drug-Sensitive Tuberculosis in Human Immunodeficiency Virus-Negative Patients

• DOI: 10.1097/00004728-200405000-00011
• Publication Date: 2004-09-02T02:21:48Z
• Authors: Hyo-Cheol Kim; Jin Mo Goo; Hyun Ju Lee; Seong Ho Park; Chang Min Park; Tae Jung Kim; Jung-Gi Im
• Keywords: Adult; Male; Adolescent; Middle Aged; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; HIV Seronegativity; Tuberculosis, Multidrug-Resistant; Humans; Female; Tomography, X-Ray Computed; Tuberculosis, Pulmonary; Aged

To compare the computed tomography (CT) features of patients with multidrug-resistant tuberculosis with those of patients with drug-sensitive tuberculosis in a country not associated with the human immunodeficiency virus (HIV) epidemic.The CT images of 47 patients with multidrug-resistant tuberculosis were compared with those of 47 patients with drug-sensitive tuberculosis as a control group. Each multidrug-resistant tuberculosis patient was age (decade) and gender matched to a drug-sensitive tuberculosis patient. All patients were seronegative to HIV. This study evaluated the presence of centrilobular nodules, consolidation, emphysema, bronchiectasis, lung destruction, calcified granuloma, cavitation, pleural effusion, and lymphadenopathy. A statistical comparison was performed by using the Fisher exact test for univariate analysis and a multiple logistic regression method for multivariate analysis.In univariate analysis, bronchiectasis, lung destruction, a calcified granuloma, and cavitation were more frequently observed in multidrug-resistant tuberculosis than in drug-sensitive tuberculosis. Multivariate analysis showed that cavity formation was the only significant difference between multidrug-resistant tuberculosis and drug-sensitive tuberculosis. In patients with cavitary tuberculosis, multiple cavities (>3 cavities) were observed only in patients with multidrug-resistant tuberculosis.Most patients with multidrug-resistant tuberculosis had cavity formation on CT. Although the presence of a cavity does not mean multidrug resistance, multiple cavities suggest the possibility of multidrug-resistant tuberculosis.