Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure

• DOI: 10.1097/00004872-200211000-00017
• Publication Date: 2003-04-24T11:21:03Z
• Authors: Takayoshi Ohkubo; Atsushi Hozawa; Junko Yamaguchi; Masahiro Kikuya; Kaori Ohmori; Mari Michimata; Mitsunobu Matsubara; Junichiro Hashimoto; Haruhisa Hoshi; Tsutomu Araki; Ichiro Tsuji; Hiroshi Satoh; Shigeru Hisamichi; Yutaka Imai
• Keywords: Male; Blood Pressure; Blood Pressure Determination; Middle Aged; Prognosis; Circadian Rhythm; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Risk Factors; Hypertension; Humans; Female; Prospective Studies; Aged; Follow-Up Studies

To examine the relationship between normal nocturnal decline in blood pressure and risk of cardiovascular mortality individuals with without high 24-h values.We obtained ambulatory readings from 1542 residents Ohasama, Japan, who were aged 40 years or more representative Japanese general population. We then followed up their survival for a mean 9.2 years. The was analysed using Cox proportional hazards model adjusted possible confounding factors.There linear mortality. On average, each 5% decrease systolic/diastolic associated an approximately 20% greater There no significant interactions values continuous ( interaction 0.6). Even when within range 135/80 mmHg, average 118/69 mmHg), diminished decreases increased mortality.This is first study to demonstrate that factor mortality, independent overall load during period,