Vulvar Intraepithelial Neoplasia

• DOI: 10.1097/01.aog.0000187301.76283.7f
• Publication Date: 2010-11-12T06:36:28Z
• Authors: Ronald W. Jones; Darion M. Rowan; Alistair W. Stewart
• Keywords: Vulvar intraepithelial neoplasia

In Brief OBJECTIVE: To determine the clinical characteristics, outcome following surgical treatment, and natural history of cases untreated vulvar intraepithelial neoplasia (VIN). METHODS: Four hundred five VIN 2–3 seen between 1962 2003 were reviewed. RESULTS: The mean age women with decreased from 50.0 years before 1980 to 39.0 in subsequent years. After treatment by excision and/or laser vaporization, half required at least one further 14th year. It is estimated that 50% positive margins had within 5 years, but only 15% negative treatment. Invasive vulvar, perianal, or urethral carcinoma occurred 17 (3.8%) (mean 42 years) after Nine (2%) represented failure, a median treatment-to-invasion interval 2.4 Eight (1.8%) new "field" carcinomas, initial 13.5 Ten cases, aged 32–76 55 years), progressed invasion 1.1–7.3 3.9 years). Age, previous pelvic radiotherapy, unifocality, immunosuppression, association multicentric not risk factors for development invasive this study. Spontaneous regression 47 24.6 complete 9.5 months. CONCLUSION: Surgically treated has high rate recurrence. Untreated over 30 an appreciable potential. LEVEL OF EVIDENCE: II-3 potential while spontaneous may occur younger women.