Regulatory CD25+ T Cells in Human Kidney Transplant Recipients

• DOI: 10.1097/01.asn.0000057540.98231.c1
• Publication Date: 2004-10-23T14:37:06Z
• Authors: Alan D. Salama; Nader Najafian; Michael R. Clarkson; William E. Harmon; Mohamed H. Sayegh
• Keywords: Immunosuppression

Recent evidence suggests that a population of professional regulatory cells, which limit immune responsiveness, exist in rodents and healthy human subjects. However, their role disease states remains unclear. A proportion renal transplant recipients do not demonstrate vitro reactivity toward mismatched donor-derived HLA-DR antigens; it was therefore hypothesized this may be due to such cells. cohort 23 studied at single institution. In patients with no history acute rejection, 6 (40%) 15 demonstrated regulation the allopeptides by CD25(+) By contrast, only one (12.5%) eight those rejection regulation. Interestingly, if patient assays were stratified according initial responsiveness allopeptides, 8 (47.1%) 17 low allopeptide (alloreactive T cell frequencies less than 60/million) indirect pathway alloresponses whereas 0 higher responses (frequencies greater (P < 0.05 chi(2) test). The cells are present circulation as early 3 mo after transplantation persist for number years, despite conventional immunosuppression. Furthermore, induction treatment anti-IL-2R mAb did prevent development these Data from two suggest also play preventing epitope shifting, implicated ongoing activation contributing chronic loss given precede an episode rejection.