Systemic and renal macro- and microcirculatory responses to arginine vasopressin in endotoxic rabbits*

• DOI: 10.1097/01.ccm.0000139708.10718.e3
• Publication Date: 2004-08-31T15:40:17Z
• Authors: Martin Albert; Marie-Reine Losser; David Hayon; Valérie Faivre; Didier Payen
• Keywords: Mean arterial pressure; Renal circulation

Arginine vasopressin is being used increasingly to treat vasodilatory hypotension, although little known of its effects on regional perfusion. hemodynamic in physiology are mainly mediated through the V1a receptor blood vessels. To investigate this further, we studied effect arginine systemic and renal flow anesthetized, ventilated rabbits given either intravenous saline or endotoxin, impact blocking receptors.Prospective, randomized, controlled study.Animal research laboratory.Male White New Zealand rabbits.Measurement was made mean arterial pressure, aortic velocities (pulsed Doppler), cortical medullary (laser Doppler).In a first series animals, incremental boluses ranging from 1 1000 ng were administered 90 mins postendotoxin saline. In control (n = 9), increasing doses elevated pressure but reduced both velocity (p <.05). endotoxic animals 6), produced similar increase maintained while increased, mostly diastolic component Pretreatment with antagonist second blunted all observed 5) 6) suggesting that acted subtype early phase sepsis.Preservation during endotoxemia, particular cortex, suggests it could be promising agent for support septic shock.