Prenatal PCB Exposure and Thyroid Function at Birth

• DOI: 10.1097/01.ede.0000392196.85327.e6
• Publication Date: 2010-12-14T09:06:58Z
• Authors: Lubica Palkovicova; Henrieta Patayova; Katarina Rausova; Jana Babjakova; Jana Chovancova; Kamil Conka; Anna Fabisikova; Eva Sovcikova; Tomas Trnovec
• Keywords: Cord blood; Thyroid-stimulating hormone

PP-31-119 Background/Aims: Michalovce region in the Eastern Slovakia was characterized by intense polychlorinated biphenyls (PCB) production within 1959–1984; although it stopped 80s, substantial environmental PCB contamination still exists. We assessed effect of prenatal exposure on thyroid functions mothers with newborns born Michalovce. Methods: Mothers (N = 220) were recruited after hospital admission for delivery, and samples maternal cord blood sera collected. Concentrations hormones (thyroid stimulating hormone, tT3, fT4) measured using electrochemiluminescence immunoassay. Congener-specific analysis PCBs done high-resolution mass spectrometry. Twenty-seven congeners (74, 66, 99, 118, 105, 146, 153, 138, 167, 156, 157, 178, 187+182, 183, 177, 171, 172+192, 180, 170+190, 189, 202, 199, 196+203, 195, 194, 206, 209) minimal amount 66% concentrations more than limit detection used further assessment. Results: The mean median levels sum 809 467 ng/g lipids 667 381 newborns; significantly correlated between (r 0.87, P < 0.001). Using multivariate regression analysis, significant positive associations fT4 tT3 found, without changes hormone levels. Conclusion: Differences our results some published data function may be explained specific conditions eastern Slovakia; is relatively high long-term this region. However, agree adult Slovak population living (Langer et al, Chemosphere. 2007;70:110–118). Grants from Ministry Health Republic, no. 2005/34-SZU-12 2005/34-SZU-13.