PS 02-49 ASSOCIATION OF MATRIX METALLOPROTEINASES WITH THE RENAL BLOOD FLOW AND RENAL FUNCTION IN PATIENTS WITH RESISTANT HYPERTENSION AND TYPE 2 DIABETES MELLITUS

• DOI: 10.1097/01.hjh.0000500176.07822.2d
• Publication Date: 2016-09-17T16:41:53Z
• Authors: Alla Falkovskaya; Victor Mordovin; Stanislav Pekarskyi; Galina Semke; Tatyana Ripp; Irina Zyubanova; Tamara Ryabova; Anna Gusakova
• Keywords: Microalbuminuria; Basal (medicine)

Objective: We wished to assess the relationship between plasma concentrations of matrix metalloproteinases (MMP) and their tissue inhibitors with intrarenal vascular resistance level, renal function development microalbuminuria in patients resistant hypertension (RH) type 2 diabetes mellitus (DM). Design Method: A total 18 RH DM were included study (mean aged 58.6 ± 7.5 years, 6 male, office blood pressure (BP) 174.4 20.2/94.1 15.2 mmHg, basal glycaemia 8.8 2.3 mmol/L, HbA1c 6.8 0.7%, an estimated glomerular filtration rate (eGFR) 74.2 27.9 mL/min/1.73m 2), which submitted BP measurements, Doppler ultrasound laboratory tests (defined as 30–300 mg/24 h), eGFR (MDRD formula), levels, MMP-9, MMP-2, inhibitor MMP 1 (TIMP-1). Results: Decreased MMP-9 concentration was linearly associated increased resistive index (RI) arteries (in main arteries: R = −0.60, p 0.009 (right), 0.−60, 0.008 (left); segmental −0.49, P 0.038 (right) −0.59, 0.012 (left)), while growth TIMP-1/MMP-9 ratio positively correlated RI at (R 0.51, 0.028- on right, 0.46, 0.04- left). Additionally, decreased 0.53, 0.029). No correlation observed TIMP-1, TIMP-1/MMP-9, TIMP-1/MMP-2 ratios microalbuminuria, however, microalbuminuric had a higher than normoalbuminuric (2.97(2.15–3.80) 1.58(1.39–1.99)ng/mL, accordingly, 0.026). Besides, [2.97 (2.15–3.80) 1.58 (1.39–1.99), 0.026)]. Conclusions: In activity are decline function. Furthermore, these due primarily increase level linked microalbuminuria.