IMMUNE AND METABOLIC DISORDERS IN HYPERTENSION, OBESITY, AND HEPATIC STEATOSIS ASSOCIATE WITH PPAR-GAMMA2 PRO12ALA AND ACE I/D GENES’ POLYMORPHISMS

• DOI: 10.1097/01.hjh.0000941324.76229.99
• Publication Date: 2023-06-08T09:09:45Z
• Authors: Valentina Dzhuriak; Larysa Sydorchuk; Kseniia Voroniuk; Ruslan Sydorchuk; Alina Sokolenko; Yulia Repchuk; Marianna Semianiv; Oksana Iftoda
• Keywords: Steatosis; Lipid Profile; Pathogenesis

Objective: Metabolic changes and obesity play important roles in arterial hypertension pathogenesis progression. Whereas hepatic steatosis (HS) AH have multiple common mechanisms of development involving metabolic immune changes, the aim study was to investigate influence Pro12Ala polymorphism PPAR-↖2 gene I/D ACE on profile cytokines obese patients with HS AH. Design method: Study involved 154 (87 males, 67 females, age 50.06±7.34). Duration 1-5 years, 3-21 years. disorders were defined body mass index (BMI), glycaemia, immunoreactive insulin (IRI), total cholesterol (TC), low high density (LDL-C, HDL-C), triglycerides (TG), C-peptide (CP) levels HOMA-IR index. TNF- ↑ leptin plasma assessed by ELISA. Genes’ (Pro12Ala), (I/D) alone or combination studied PCR. Results: Differences BMI, glucose, IRI, HOMA-IR, CP are independent from genotypes (p>.05). Pro-allele carriers higher BMI than AlaAla (32.7±2.1 27.9±1.1 kg/m 2 vs 25.6±0.8 , accordingly (p<.05), level – 14.3±0.41 8.6±0.25 ng/ml 3.7±0.22 ng/ml, (p<.001), glucose 10.2% 10.9% (p<.05); ProPro-genotype Ala-allele 15.7% (p<.05). Risk group dyslipidemia TC, TG LDL-C 16.4%, 17.3% 27.9% (p<.05) lower HDL-C women 25.6% (p = .038). Lipids polymorphism. Baseline TNF-↑ did not significantly deviate between gene, but D-allele (I/D+DD) had baseline (91.61 109.11 pg/ml, p<.01). Conclusions: In hypertensive clearly associated (carbohydrates) (lipids). Presence is reliably levels.