SIGNIFICANT INCREASES IN PERIPHERAL AND CENTRAL BLOOD PRESSURE IN CHILDREN AT MUCH LOWER BODY MASS INDEX THAN EXPECTED

• DOI: 10.1097/01.hjh.0001019420.16281.8a
• Publication Date: 2024-05-22T10:01:54Z
• Authors: Lisa Wilmsmeier; Jeannine Von Der ...; Rizky I Sugianto; Carl Grabitz; Bernhard Mw Schmidt; Ana Celine Braun; Denise Homeyer; Uwe Tegtbur; Anette Melk
• Keywords: 03 medical and health sciences; 0302 clinical medicine

Objective: Cardiovascular (CV) complications are the most common causes of death worldwide. Increased body weight and higher blood pressure (BP) known risk factors for CV disease with a association mass index (BMI) BP. Our study intended to describe at which BMI-level significant increases in either central (cBP) or peripheral BP (pBP) can be detected young children. Design method: We measured cBP pBP 1,183 schoolchildren (first/second graders; mean age 7.9±0.6 years; 51% male). measurements were performed validated oscillometric device (Dinamap-VC150-GE). was noninvasively Mobil-O-Graph (IEM). Multivariable linear regression models (corrected age, sex, height) used compare pBP/cBP values children BMI<50th percentile (pct) separated five groups according BMI pct (>=50th-<65thpct; >=65th-<75thpct; >=75th-<85thpct; >=85th-<95thpct; >=95thpct). Results: 17±3 kg/m 2 (M±SD), 275 (22.8%) overweight (BMI>=85th pct), 126 (10.5%) obese (BMI>=95thpct). Peripheral systolic (pSBP) 104±8mmHg diastolic (pDBP) 61±6mmHg (M±SD); 5% cohort displayed hypertensive >=95thpct. In unadjusted analysis, we saw an increase pSBP (Fig.1A) cSBP (Fig.1B) already around 60thpct. Further analysis comparing corrected means revealed that showed BMI>=75thpct (ß=1.8, p=0.026) when compared BMI<50thpct. For model including pDBP no effects seen. significantly increased >=65thpct. (ß=1.7, p=0.031), while cDBP >=75thpct (ß=1.5; p=0.012) Conclusions: findings suggest affect particularly much lower level than expected. These results alarming as pediatricians usually get concerned levels above 85thpct (defined cut-off based on WHO growth reference values). Given important interaction between both their track from childhood adulthood, effective prevention must take place early childhood.