BLOOD PRESSURE EFFECTS OF TRAZODONE IN HYPERTENSIVE OLDER ADULTS

• DOI: 10.1097/01.hjh.0001019672.66582.a4
• Publication Date: 2024-05-22T10:04:44Z
• Authors: Marco Capacci; Giulia Rivasi; Ludovica Ceolin; Giada Turrin; Lorenza Rossi; Silvia Menale; Maria Francesca B...; Alessandra Liccardo; Enrico Mossello; Andrea Ungar
• Keywords: Trazodone

Objective: Trazodone is commonly prescribed in older adults and may have hypotensive effects due to the inhibition of alpha-adrenergic receptors. The present study aimed investigate trazodone on blood pressure (BP) its related risk syncope falls hypertensive adults. Design method: A longitudinal observational involving patients aged 75 or was conducted at Hypertension Clinic Memory Division Geriatric Intensive Care Medicine, Careggi Hospital, Florence. Participants underwent multidimensional geriatric assessment including office BP measurement, 3-minute active stand test (BP measurement immediately after standing [T0] 1 [T1] 3 minutes [T3]), home ambulatory monitoring. composite outcome assessed 12 months association with analysed using multivariate Cox regression analysis. Results: Among 123 participants (mean age 81 years, 59% female), (10%) reported regular use. receiving showed lower diastolic (71.8 mmHg vs. 80.1 mmHg, p=0.042) a greater systolic reduction (δsystolicT0 16.2 9.7 p=0.038; δdiastolicT0 11 1.7 p=0.003). No differences were as regards BP. Incidence 25%, significantly higher rate (58.3% 21.2%, p=0.005). associated an increased independently physical performance (HR 2.654, 95% CI 1.104 - 6.378). This not confirmed when analysis adjusted for dementia diagnosis 1.874, 0.736 – 4.773; HR 2.556, 1.018 6.419). Conclusions: In hypertension, orthostatic drop might increase falls.