Antibiotic-Resistant Helicobacter pylori Strains in Portuguese Children

• DOI: 10.1097/01.inf.0000160941.65324.6b
• Publication Date: 2005-05-05T08:01:03Z
• Authors: Ana Isabel Lopes; Mónica Oleastro; Ana Palha; Afonso Fernandes; Lurdes Monteiro
• Keywords: Urea breath test

Background: Data concerning the effectiveness of Helicobacter pylori eradication regimens based in antibiotic susceptibility testing are scanty children. Aims: To identify prevalence resistance H. strains isolated from Portuguese children 1999–2003; to evaluate rate after testing-based treatment; and factors associated with outcome. Methods: Included were 109 a gastric biopsy culture positive for pylori. First treatment (amoxicillin, omeprazole clarithromycin or metronidazole) was guided by (E test), assessed [13C]urea breath test. Results: Strains susceptible amoxicillin tetracycline; 39.4% resistant clarithromycin, 16.5% metronidazole 4.5% ciprofloxacin. No significant association found between sex, age, clinical status, gastritis scores, density scores genotype. Clarithromycin significantly European origin [odds ratio (OR), 3.9], previous empiric therapy (OR 2.8) minimal inhibitory concentration, ≥0.016 6.0). Eradication susceptibility-based 74.7% (59 79; 95% confidence interval, 65.9–82.9), failure presence 1 more antibiotics (P < 0.05). Conclusions: The high studied population. modest therapeutic success suggests that addition resistance, other may be involved. need studies antimicrobial surveillance areas emphasized.