High Prevalence of Human Cytomegalovirus in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma

• DOI: 10.1097/01.ju.0000080263.46164.97
• Publication Date: 2003-11-18T22:15:08Z
• Authors: MINU SAMANTA; LUALHATI HARKINS; KATRIN KLEMM; WILLIAM J. BRITT; CHARLES S. COBBS
• Keywords: Neoplastic transformation; Prostatic Diseases; Carcinoma in situ

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Sep 2003High Prevalence Human Cytomegalovirus in Prostatic Intraepithelial Neoplasia and Carcinoma MINU SAMANTA, LUALHATI HARKINS, KATRIN KLEMM, WILLIAM J. BRITT, CHARLES S. COBBS SAMANTAMINU SAMANTA , HARKINSLUALHATI HARKINS KLEMMKATRIN KLEMM BRITTWILLIAM BRITT COBBSCHARLES View All Author Informationhttps://doi.org/10.1097/01.ju.0000080263.46164.97AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Recent epidemiological data indicate that a history increased exposure sexually transmitted diseases is associated with an risk prostate cancer. cytomegalovirus (HCMV) member the herpesvirus family, adults can persistently infect prostatic epithelium nonimmunocompromised hosts. Based on awareness oncogenic potential this virus, we decided reexplore issue whether HCMV might be involved cancer pathogenesis. Materials Methods: Paraffin embedded biopsy specimens from 22 randomly selected patients intraepithelial neoplasia (PIN) lesions carcinoma were analyzed by immunohistochemistry, situ hybridization, polymerase chain reaction DNA sequencing detect nucleic acids determine gene products specifically neoplastic cells. Results: We detected proteins and/or all preneoplastic evaluated. often highly expressed basal cell hyperplasia PIN lesions, lesser degree To our knowledge these demonstrate for first time specific localization high percent raise possibility contribute natural References 1 : Prostate cancer: current perspective. Epidemiol Rev1991; 13: 200. Google Scholar 2 Meta-analysis measures sexual activity Epidemiology2002; 72. 3 Sexual behaviour, STDs risks Br J Cancer2000; 82: 718. 4 viruses. In: Cancer: Principles Practice Oncology, 6th ed. Edited . Philadelphia: Lippincot Williams Wilkins Co.2001: 168. 5 Cytomegalovirus. Fields Virology. New York: Raven Press1996: 2493. 6 prostatitis. Urology1992; 40: 165. 7 immediate early growth control. Gene2002; 290: 19. 8 human genes transform transactivate. Clin Microbiol Rev1999; 12: 367. 9 Evidence association prostate. Urol1977; 118: 789. Link, 11 Long-term persistence genome cultured cells origin. Virol1975; 16: 982. 12 infection expression malignant glioma. Cancer Res2002; 62: 3347. 13 gpUL73 (gN) genomic variants isolates are clustered into four distinct genotypes. Gen Virol2001; 2777. 14 Persistent induces drug resistance alteration programmed death neuroblastoma Res1998; 58: 15 The 72K IE1 80K IE2 independently trans-activate c-fos, c-myc hsp70 promoters via promoter elements. Virol1992; 73: 2385. 16 Potential role p53 interaction coronary restenosis. Science1994; 265: 391. 17 Immune evasion cytomegalovirus: lessons immunology biology. Semin Immunol2001; 41. 18 Molecular genetics Genes Dev2000; 14: 2410. From Surgical Service, Veterans Affairs Medical Center (MS, LH, CSC) Departments Surgery (CSC), Pathology (KK) Pediatrics (WJB), University Alabama at Birmingham, Alabama© 2003 American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byXiao W, Wang J, Li H, Guan Xia D, Yu G, Xiao Lang B, Ma X, Liu Zhang Ye Z Xu H (2018) Fibulin-1 Down-Regulated Through Promoter Hypermethylation Suppresses Renal Cell ProgressionJournal Urology, VOL. 190, NO. 1, (291-301), Online publication date: 1-Jul-2013. Volume 170 Issue September Page: 998-1002 Advertisement Copyright & Permissions© Inc.Keywordsprostateprostatic neoplasmscytomegalovirus virus infectionssexually diseasesMetrics Information More articles author Expand PDF downloadLoading ...