PD39-07 DIAGNOSTIC ACCURACY OF POST-CRYOABLATION MRI FOR RESIDUAL PROSTATE CANCER

• DOI: 10.1097/01.ju.0001008924.16121.42.07
• Publication Date: 2024-04-15T21:33:57Z
• Authors: Piroz Bahar; Eugene Oh; Karan Desai; Matthew Jordan; Matthew Davenport; Jeffrey S. Montgo...; Arvin K. George
• Keywords: Cryoablation; Cryosurgery

You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy II (PD39)1 May 2024PD39-07 DIAGNOSTIC ACCURACY OF POST-CRYOABLATION MRI FOR RESIDUAL PROSTATE CANCER Piroz Bahar, Eugene Oh, Karan Desai, Matthew Jordan, Davenport, Jeffrey S. Montgomery, and Arvin K. George BaharPiroz Bahar , OhEugene Oh DesaiKaran Desai JordanMatthew Jordan DavenportMatthew Davenport MontgomeryJeffrey Montgomery GeorgeArvin View All Author Informationhttps://doi.org/10.1097/01.JU.0001008924.16121.42.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Assessing oncological success following focal ablation for prostate cancer (PCa) includes PSA response imaging. However, the value protocol biopsy remains uncertain. Consensus recommendations include follow-up multi-parametric (mpMRI) despite variable imaging quality, interpretation, performance. We aim determine mpMRI performance characteristics post-ablation in-field (within zone) failure cryoablation. METHODS: Patients receiving cryoablation from 01/01/2017 04/21/2023 were enrolled in a multi-institutional, IRB-approved, prospective registry. Per protocol, PSA, mpMRI, ultrasound-MR fusion bed obtained at 6 months post-ablation. Residual PCa was suspected on if there persistent enhancement impeded diffusion within intended zone. Sensitivity, specificity, positive predictive (PPV), negative (NPV) Gleason Grade Group (GG) ≥2 calculated. Chi-squared test used perform bivariate analysis. RESULTS: 108 patients undergoing 118 cryoablations enrolled. Patient-level are presented Table 1. Post-primary performed 91 patients; 10 underwent repeat Seven post-repeat (N=98 events). Post-ablation showed possible residual 11.2% (11/98). target lesion GG≥2 10.2% (10/98) patients. MpMRI sensitivity, PPV, NPV detecting 71.4%, 95.3%, 55.6%, 97.6%, respectively. Primary analysis significant association between suspicion disease detection [p<0.0001]. Secondary excluding data (N=91) 94.9%, 97.4%, CONCLUSIONS: has high NPV, sensitivity when negative, could be defer near-term "protocol" biopsy. Future investigation into causes false will help identify those who warrant per-protocol Source Funding: N/A © 2024 by American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e815 Advertisement Copyright & Permissions© Inc.Metrics Information More articles this author Expand PDF downloadLoading ...