Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed

• DOI: 10.1097/01.mjt.0000178338.43545.3a
• Publication Date: 2006-11-21T12:34:59Z
• Authors: Alan D Kaye; Jason M Hoover; Ikhlass N Ibrahim; James Phelps; Amir Baluch; Aaron Fields; Shane Huffman
• Keywords: Pulmonary Circulation; Dose-Response Relationship, Drug; Naloxone; Narcotic Antagonists; Vasodilator Agents; Blood Pressure; Pulmonary Artery; Bradykinin; Nitric Oxide; 3. Good health; Analgesics, Opioid; Fentanyl; Vasodilation; Norepinephrine; 03 medical and health sciences; Diphenhydramine; 0302 clinical medicine; Cyclooxygenase 2; Receptors, Opioid; Cats; Histamine H1 Antagonists; Animals; Histamine

The objective of this study was to test the hypothesis that fentanyl induces a depressor response in pulmonary vascular bed cat and identify receptors involved mediation or modulation these effects. authors conducted prospective vehicle-controlled at university research laboratory using intact chest preparation adult mongrel cats. In separate experiments, effects diphenhydramine (histamine receptor blocker), glibenclamide (ATP-sensitive K+ channel l-N5-(1-Iminoethyl) ornithine hydrochloride (l-NIO) (nitric oxide synthase inhibitor), nimesulide (selective cyclooxygenase [COX]-2 naloxone (opiate antagonist) were investigated on arterial responses other agonists cat. systemic pressure lobar perfusion continuously monitored, electronically averaged, recorded. feline isolated left lower lobe, induced dose-dependent vasodepressor not significantly altered after administration glibenclamide, l-NIO, nimesulide. However, attenuated naloxone. results present suggest has potent activity may be mediated modulated by both histaminergic opiate sensitive pathways.