Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed

Pulmonary Circulation Dose-Response Relationship, Drug Naloxone Narcotic Antagonists Vasodilator Agents Blood Pressure Pulmonary Artery Bradykinin Nitric Oxide 3. Good health Analgesics, Opioid Fentanyl Vasodilation Norepinephrine 03 medical and health sciences Diphenhydramine 0302 clinical medicine Cyclooxygenase 2 Receptors, Opioid Cats Histamine H1 Antagonists Animals Histamine
DOI: 10.1097/01.mjt.0000178338.43545.3a Publication Date: 2006-11-21T12:34:59Z
ABSTRACT
The objective of this study was to test the hypothesis that fentanyl induces a depressor response in pulmonary vascular bed cat and identify receptors involved mediation or modulation these effects. authors conducted prospective vehicle-controlled at university research laboratory using intact chest preparation adult mongrel cats. In separate experiments, effects diphenhydramine (histamine receptor blocker), glibenclamide (ATP-sensitive K+ channel l-N5-(1-Iminoethyl) ornithine hydrochloride (l-NIO) (nitric oxide synthase inhibitor), nimesulide (selective cyclooxygenase [COX]-2 naloxone (opiate antagonist) were investigated on arterial responses other agonists cat. systemic pressure lobar perfusion continuously monitored, electronically averaged, recorded. feline isolated left lower lobe, induced dose-dependent vasodepressor not significantly altered after administration glibenclamide, l-NIO, nimesulide. However, attenuated naloxone. results present suggest has potent activity may be mediated modulated by both histaminergic opiate sensitive pathways.
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