Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed

• DOI: 10.1097/01.mjt.0000178338.43545.3a
• Publication Date: 2006-11-21T12:34:59Z
• Authors: Alan D Kaye; Jason M Hoover; Ikhlass N Ibrahim; James Phelps; Amir Baluch; Aaron Fields; Shane Huffman
• Keywords: Pulmonary Circulation; Dose-Response Relationship, Drug; Naloxone; Narcotic Antagonists; Vasodilator Agents; Blood Pressure; Pulmonary Artery; Bradykinin; Nitric Oxide; 3. Good health; Analgesics, Opioid; Fentanyl; Vasodilation; Norepinephrine; 03 medical and health sciences; Diphenhydramine; 0302 clinical medicine; Cyclooxygenase 2; Receptors, Opioid; Cats; Histamine H1 Antagonists; Animals; Histamine

The objective of this study was to test the hypothesis that fentanyl induces a depressor response in the pulmonary vascular bed of the cat and to identify the receptors involved in the mediation or modulation of these effects. The authors conducted a prospective vehicle-controlled study at a university research laboratory using intact chest preparation in adult mongrel cats. In separate experiments, the effects of diphenhydramine (histamine receptor blocker), glibenclamide (ATP-sensitive K+ channel blocker), L-N5-(1-Iminoethyl) ornithine hydrochloride (L-NIO) (nitric oxide synthase inhibitor), nimesulide (selective cyclooxygenase [COX]-2 inhibitor), and naloxone (opiate receptor antagonist) were investigated on pulmonary arterial responses to fentanyl and other agonists in the pulmonary vascular bed of the cat. The systemic pressure and lobar arterial perfusion pressure were continuously monitored, electronically averaged, and recorded. In the feline pulmonary vascular bed of the isolated left lower lobe, fentanyl induced a dose-dependent vasodepressor response that was not significantly altered after administration of glibenclamide, L-NIO, and nimesulide. However, the responses to fentanyl were significantly attenuated after administration of diphenhydramine and naloxone. The results of the present study suggest that fentanyl has potent vasodepressor activity in the pulmonary vascular bed of the cat and that this response may be mediated or modulated by both histaminergic and opiate receptor sensitive pathways.