Analysis of the Effects of Fentanyl in the Feline Pulmonary Vascular Bed
Pulmonary Circulation
Dose-Response Relationship, Drug
Naloxone
Narcotic Antagonists
Vasodilator Agents
Blood Pressure
Pulmonary Artery
Bradykinin
Nitric Oxide
3. Good health
Analgesics, Opioid
Fentanyl
Vasodilation
Norepinephrine
03 medical and health sciences
Diphenhydramine
0302 clinical medicine
Cyclooxygenase 2
Receptors, Opioid
Cats
Histamine H1 Antagonists
Animals
Histamine
DOI:
10.1097/01.mjt.0000178338.43545.3a
Publication Date:
2006-11-21T12:34:59Z
AUTHORS (7)
ABSTRACT
The objective of this study was to test the hypothesis that fentanyl induces a depressor response in pulmonary vascular bed cat and identify receptors involved mediation or modulation these effects. authors conducted prospective vehicle-controlled at university research laboratory using intact chest preparation adult mongrel cats. In separate experiments, effects diphenhydramine (histamine receptor blocker), glibenclamide (ATP-sensitive K+ channel l-N5-(1-Iminoethyl) ornithine hydrochloride (l-NIO) (nitric oxide synthase inhibitor), nimesulide (selective cyclooxygenase [COX]-2 naloxone (opiate antagonist) were investigated on arterial responses other agonists cat. systemic pressure lobar perfusion continuously monitored, electronically averaged, recorded. feline isolated left lower lobe, induced dose-dependent vasodepressor not significantly altered after administration glibenclamide, l-NIO, nimesulide. However, attenuated naloxone. results present suggest has potent activity may be mediated modulated by both histaminergic opiate sensitive pathways.
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