The Doublecortin Gene, A New Molecular Marker to Detect Minimal Residual Disease in Neuroblastoma

• DOI: 10.1097/01.pas.0000149876.32376.c0
• Publication Date: 2005-02-14T09:01:09Z
• Authors: Silvestre Oltra; Francisco Martinez; Carmen Orellana; Elena Grau; Jose M Fernandez; Adela Ca??ete; Victoria Castel
• Keywords: Doublecortin; Minimal Residual Disease

Neuroblastoma (NB) is a pediatric cancer of highly variable clinical outcome. Much effort devoted to detection minimal residual (MRD) disease through RT-PCR or immunology tissue-specific markers. Tyrosine hyrdroxylase (TH) has demonstrated high utility assess dissemination, although this marker can be lost due clonal variability. Here we propose the use doublecortin (DCX) gene as new molecular neuroblastoma cells. DCX specifically appears in migrating neurons central and peripheral nervous system interacts with regulates microtobule cytoskeleton. We have studied by real-time quantitative total 47 primary tumors 202 samples bone marrow blood from 34 high-risk patients well 41 normal controls. The expression good specificity concordance TH, showing higher rate all sample types at different time points diagnosis. conclude that would more efficient perhaps other neuronal lineage.