D-105 Integrin a4b7 expression increases HIV susceptibility in activated cervical CD4+ T cells via an HIV attachment- independent mechanism

• DOI: 10.1097/01.qai.0000479553.52108.e7
• Publication Date: 2016-01-15T02:18:23Z
• Authors: Jian Ding; Carley Tasker; Pierre Lespinasse; Jihong Dai; Patricia Fitzgera...; Wuyuan Lu; Debra Heller; Theresa Chang
• Keywords: 0303 health sciences; 03 medical and health sciences

Background: CD4+ T cells, the principal target in acute SIV and HIV infection, are crucial for establishment dissemination of infection mucosal tissues. Studies indicate that α4β7 cells preferentially infected by vitro during infection. The integrin is thought to promote capture cells; however, role transmission remains controversial. In this study, we characterized immune phenotypes human cervical examined preference α4β7+ cells. all-trans retinoic acid differentiated peripheral (at-RA cells) were included as a comparison. Results: both majority p24+ activated expressing α4β7. Among at-RA frequency CCR5 expression was higher than p24- no such difference observed Neither cyclic hexapeptide CWLDVC nor monoclonal antibody against blocked attachment or gp120 binding regardless presence CD4, indicating did not facilitate Conclusions: Integrin increases susceptibility, but mechanism through promoting