Potential of Human Bone Marrow Stromal Cells to Accelerate Wound Healing in Vitro

• DOI: 10.1097/01.sap.0000178809.01289.10
• Publication Date: 2005-09-23T08:01:35Z
• Authors: Seung-Kyu Han; Tae-Hwan Yoon; Dong-Geun Lee; Min-Ah Lee; Woo-Kyung Kim
• Keywords: Human bone

The purpose of this pilot study was to compare proliferation, collagen synthesis, and growth factor production, which are important contributing factors for wound healing, the bone marrow stromal cells (BSCs) with those dermal fibroblasts in vitro. Cultured human BSCs from same patients were seeded 96-well culture plates. At 1, 3, 5 days postincubating, cell secretion basic fibroblast (bFGF), vascular endothelial (VEGF), transforming beta (TFG-beta) compared. We did not observe great differences proliferation TFG-beta secretion. In contrast, amount synthesis levels bFGF VEGF much higher BSC group than at each time interval (P < 0.05). Our results suggest that may have superior potential accelerate healing fibroblasts.