Safety of Atomoxetine in Combination With Intravenous Cocaine in Cocaine-Experienced Participants

Adult Male Blood Pressure Comorbidity Atomoxetine Hydrochloride Drug Administration Schedule Cocaine-Related Disorders Electrocardiography 03 medical and health sciences Cognition 0302 clinical medicine Cocaine Double-Blind Method Heart Rate Humans Drug Interactions Motivation Adrenergic Uptake Inhibitors Dose-Response Relationship, Drug Middle Aged 16. Peace & justice 3. Good health Affect Attention Deficit Disorder with Hyperactivity
DOI: 10.1097/adm.0b013e31826b767f Publication Date: 2012-09-15T11:37:45Z
ABSTRACT
Atomoxetine has been considered as an agonist replacement therapy for cocaine. We investigated the safety of interaction atomoxetine with cocaine and also whether cognitive function was affected by during short-term administration.In a double-blind placebo-controlled inpatient study 20 cocaine-dependent volunteers, participants received 80 mg daily followed 100 5 days each. On fourth fifth day at each dose, (20 40 mg) infused intravenously in sequential sessions.Preinfusion mean systolic pressures showed small but statistically significant difference between placebo both doses atomoxetine. Preinfusion diastolic were only. The pressure response to only 80- 100-mg doses. All electrocardiogram parameters unchanged. Visual Analog Scale (VAS) scores "bad effect" group significantly higher baseline, then declined, "likely use" declined treatment. Addiction Research Center Inventory, scored lower on amphetamine, euphoria, energy subscales (P < 0.0001). Other VAS descriptors, Brief Substance Craving Scale, Profile Moods State, Psychiatric Rating no differences. did not affect pharmacokinetics. In tests working memory, sustained attention, flexibility, decision-making, improved performance visual n-back task. There differences any pharmacokinetic atomoxetine.Atomoxetine tolerated safely all participants. Certain improvements dampening effect after observed, should be weighed against hemodynamic responses
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