Safety of Atomoxetine in Combination With Intravenous Cocaine in Cocaine-Experienced Participants

• DOI: 10.1097/adm.0b013e31826b767f
• Publication Date: 2012-09-15T11:37:45Z
• Authors: Louis Cantilena; Roberta Kahn; Connie C. Duncan; Shou-Hua Li; Ann Anderson; Ahmed Elkashef
• Keywords: Adult; Male; Blood Pressure; Comorbidity; Atomoxetine Hydrochloride; Drug Administration Schedule; Cocaine-Related Disorders; Electrocardiography; 03 medical and health sciences; Cognition; 0302 clinical medicine; Cocaine; Double-Blind Method; Heart Rate; Humans; Drug Interactions; Motivation; Adrenergic Uptake Inhibitors; Dose-Response Relationship, Drug; Middle Aged; 16. Peace & justice; 3. Good health; Affect; Attention Deficit Disorder with Hyperactivity

Atomoxetine has been considered as an agonist replacement therapy for cocaine. We investigated the safety of interaction atomoxetine with cocaine and also whether cognitive function was affected by during short-term administration.In a double-blind placebo-controlled inpatient study 20 cocaine-dependent volunteers, participants received 80 mg daily followed 100 5 days each. On fourth fifth day at each dose, (20 40 mg) infused intravenously in sequential sessions.Preinfusion mean systolic pressures showed small but statistically significant difference between placebo both doses atomoxetine. Preinfusion diastolic were only. The pressure response to only 80- 100-mg doses. All electrocardiogram parameters unchanged. Visual Analog Scale (VAS) scores "bad effect" group significantly higher baseline, then declined, "likely use" declined treatment. Addiction Research Center Inventory, scored lower on amphetamine, euphoria, energy subscales (P < 0.0001). Other VAS descriptors, Brief Substance Craving Scale, Profile Moods State, Psychiatric Rating no differences. did not affect pharmacokinetics. In tests working memory, sustained attention, flexibility, decision-making, improved performance visual n-back task. There differences any pharmacokinetic atomoxetine.Atomoxetine tolerated safely all participants. Certain improvements dampening effect after observed, should be weighed against hemodynamic responses