Preincisional Subcutaneous Infiltration of Ketamine Suppresses Postoperative Pain After Circumcision Surgery

• DOI: 10.1097/ajp.0b013e31802e3377
• Publication Date: 2007-02-15T08:58:12Z
• Authors: Ping-Heng Tan; Jiin-Tsuey Cheng; Chien-Hung Kuo; Feng-Jen Tseng; Han-Chium Chung; Jyh-I Wu; Hung-Tsung Hsiao; Lin-Cheng Yang
• Keywords: Adult; Male; Pain, Postoperative; Time Factors; Adolescent; Analgesia, Patient-Controlled; Analgesia, Epidural; 03 medical and health sciences; 0302 clinical medicine; Circumcision, Male; Double-Blind Method; Humans; Female; Ketamine; Excitatory Amino Acid Antagonists; Pain Measurement

N-methyl-D-aspartate and other glutamate receptors have been shown to present on the peripheral axons of primary afferents, injection N-methyl-D-aspartate-receptor antagonists can suppress hyperalgesia allodynia. Thus, this study examined postoperative analgesic adverse effects local ketamine administered postoperatively.Ketamine (0.3%, 3 mL) or saline was subcutaneously infiltrated before incision in a double-blind manner using sample population 40 patients undergoing circumcision surgery, equally randomly assigned 2 groups based treatment. The saline-infiltrated also received 9-mg intramuscular into upper arm control for any related systemic effects. were followed up 24 hours determine analgesia identify effects.In ketamine-infiltrated patients, time interval until first demand (166 vs. 80 min) longer incidence pain-free status (pain score=0) during movement (45% 10%) erection (40% 0%) significantly higher than saline-treated analogs (P<0.05). dose ketorolac use pain score significant lower group patients. No differences noted with respect comparing groups.We conclude that preincisional subcutaneous infiltration after surgery.