Preemptive Analgesic Effect of Ketamine in Patients Undergoing Elective Cesarean Section

• DOI: 10.1097/ajp.0b013e3181bff86d
• Publication Date: 2010-02-17T07:30:10Z
• Authors: Fazel Mohammad Reza; Forghani Zahra; Fakharian Esmaeel; Akbari Hossein
• Keywords: Elective cesarean section

In this study, the preemptive effect of a small dose ketamine on postoperative wound pain and morphine consumption in patients undergoing elective cesarean section was evaluated.In randomized, double-blind clinical trial, 60 women with American Society Anesthesiologists class I II identification were enrolled. case group, received 0.5 mg/kg ketamine, control they isotonic saline, 5 minutes before induction anesthesia. Anesthesia induced 4 thiopental followed by 1.5 succinylcholine. A further neuromuscular block achieved using 0.2 atracurium. maintained nitrous oxide 50% halothane oxygen. The lungs mechanically ventilated. After fetus delivery, fentanyl (2 microg/kg) (0.15 mg/kg) given intravenously. postanesthesia care unit ward, all morphine. Pain assessed Visual Analog Scales at 2, 6, 12, 24 hours postoperatively; amount used side effects recorded.There no significant difference between considering their operative details, homodynamic variables, effects, Apgar scores babies first fifth minutes. Significantly, lower amounts group (4.8 mg+/-2.5 mg vs. 8.1 mg+/-4.2 mg) during 2 after surgery (P=0.01), but not to (3.2+/-2.2 3.1+/-2.3). There statistical differences groups postoperatively.Intraoperative low-dose had surgery. No seen study period. preoperative administration did elicit analgesic effect.