Biomarkers of Acute Kidney Injury

• DOI: 10.1097/aln.0b013e3181cded3f
• Publication Date: 2010-03-17T05:54:34Z
• Authors: David R. McIlroy; Gebhard Wagener; H. Thomas Lee; Bruno Riou
• Keywords: Membrane Glycoproteins; Interleukin-18; Acute Kidney Injury; Lipocalins; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Lipocalin-2; Proto-Oncogene Proteins; Acetylglucosaminidase; Humans; Receptors, Virus; Hepatitis A Virus Cellular Receptor 1; Cystatin C; Biomarkers; Acute-Phase Proteins

ESPITE more than half a century of investigation,acute kidney injury (AKI) remains a major healthcareissue in medicine today. Reported to occur in 1–32% of allhospital admissions and 10–90% of intensive care unit ad-missions, the wide variation reflects different criteria used todefineAKI.However,independentofdefinition,adiagnosisof AKI is consistently associated with an increase in bothshort- and long-term morbidity and mortality. Even themildest forms of AKI are independently associated with in-creased early as well as long-term mortality, the risk increas-ing as severity of renal injury increases.