Fentanyl-sparing Effect of Acetaminophen as a Mixture of Fentanyl in Intravenous Parent-/Nurse-controlled Analgesia after Pediatric Ureteroneocystostomy

• DOI: 10.1097/aln.0b013e3181e2c34b
• Publication Date: 2010-08-06T11:07:15Z
• Authors: Jeong-Yeon Hong; Won Oak Kim; Bon Nyeo Koo; Jin Sun Cho; Eun H. Suk; Hae Keum Kil
• Keywords: Acetaminophen; Bolus (digestion); Loading dose

Background Although acetaminophen has been used widely and is well tolerated in children, its efficacy safety have not clarified when combined with an opioid intravenous parent-/nurse-controlled postoperative analgesia. Methods Sixty-three children (aged 6-24 months) who had undergone elective ureteroneocystostomies were enrolled this prospective, randomized, double-blinded study. After the surgery, analgesic pump was programmed to deliver fentanyl at a basal infusion rate of 0.25 microg.kg(-1).h(-1) microg/kg bolus after loading dose 0.5 microg/kg(-1). In fentanyl-acetaminophen group, coadministered as solution mixture 1.5 mg.kg(-1).h(-1) mg/kg 15 mg/kg, whereas saline administered group. Results Postoperative pain scores similar between two groups. The total (micrograms per kilogram day, mean+/-SD) days 1 (8.3+/-3.7 vs. 18.1+/-4.6, P=0.021) 2 (7.0+/-2.4 16.6, P=0.042) significantly less group compared that incidences vomiting (16.1 56.3%, P=0.011) sedation (9.7 46.9%, P=0.019) lower than those Conclusions Acetaminophen significant fentanyl-sparing effects reduces side analgesia for pediatric management.