Ideal Permissive Hypotension to Resuscitate Uncontrolled Hemorrhagic Shock and the Tolerance Time in Rats

• DOI: 10.1097/aln.0b013e3181fe3fe7
• Publication Date: 2010-12-18T05:30:59Z
• Authors: Tao Li; Yu Zhu; Yi Hu; Lijie Li; Youfang Diao; Jing Tang; Liangming Liu
• Keywords: Permissive; Mean arterial pressure; Hemorrhagic shock

Studies have shown that permissive hypotension for uncontrolled hemorrhagic shock can result in good resuscitation outcome. The ideal target mean arterial pressure (MAP) and the tolerance time not been determined.To elucidate MAP with rats, effects of different MAPs (40, 50, 60, 70, 80, 100 mmHg) 60-, 90-, 120-min (50 on were observed.Rats normotensive groups (80 had increased blood loss (101%, 126% total volume), decreased hematocrit, vital organ (liver kidney) mitochondrial function, animal survival rate (1 10). Rats 50- 60-mmHg (52% 69%, respectively), hematocrit stable hemodynamics, (8 10 6 10, respectively). 40-mmHg group, although having (39%), appeared to very inferior function (2 Animal 10) group significantly 60- 90-min groups. similar function.A 50-60 mmHg is shock. Ninety minutes limit; 120 min hypotensive cause severe damage should be avoided.