Developmental Effects of Neonatal Isoflurane and Sevoflurane Exposure in Rats

• DOI: 10.1097/aln.0b013e318291c04e
• Publication Date: 2013-04-25T15:00:56Z
• Authors: Christoph N. Seubert; Wanting Zhu; Christopher Pavlinec; Nikolaus Gravenstein; Anatoly E. Martynyuk
• Keywords: Bumetanide; Volatile anesthetic

The general anesthetics, isoflurane and sevoflurane, cause developmental abnormalities in neonatal animal models via incompletely understood mechanisms. Despite many common molecular targets, sevoflurane exhibit substantial differences their actions. authors sought to determine whether these can also be detected at the level of neurodevelopmental effects.Postnatal rats, 4-6 days old, were exposed 1.2% or 2.1% for 1-6 h studied immediate delayed effects.Isoflurane exposure was associated with weaker seizure-like electroencephalogram patterns than exposure. Confronted a new environment juvenile age, sevoflurane-exposed rats spent significantly more time an "immobile" state unexposed rats. Electroencephalographic (mean ± SE, 55.5 12.80 s vs. 14.86 7.03 s; P = 0.014; n 6-7) spontaneous behavior (F(2,39) 4.43; 0.018) effects diminished by pretreatment Na-K-2Cl cotransporter inhibitor bumetanide, whereas those not. Pretreatment however, isoflurane-induced activation caspase-3 cerebral cortex (F(2,8) 22.869; 0.002) prevented impairment sensorimotor gating function (F(2,36) 5.978; 0.006).These findings combination results previously reported suggest that produce acting similar mechanisms involve anesthetic-induced increase neuronal activity. At same time, mediating relative safety profile anesthesia.