Determination of Factors Affecting Glutamate Concentrations in the Whole Blood of Healthy Human Volunteers

• DOI: 10.1097/ana.0b013e3181f82a8f
• Publication Date: 2010-12-08T07:16:52Z
• Authors: Alexander Zlotnik; Sharon Ohayon; Benjamin F. Gruen...; Shaun E. Gruenbaum; Boaz Mohar; Matthew Boyko; Yael Klin; Eyal Sheiner; Gad Shaked; Yoram Shapira; Vivian I. Teichberg
• Keywords: Transaminase; Venous blood

Abnormally high concentrations of glutamate in brain fluids have been shown to be neurotoxic and correlate with a poor neurological outcome following traumatic injury (TBI). Since fluid can reduced by scavenging blood glutamate, the purpose this study was investigate factors that may potentially influence levels glucose, enzymes glutamate-pyruvate transaminase (GPT) glutamate-oxaloacetate (GOT) healthy individuals.Factors were examined included age, gender, time last meal or drink, recent consumption coffee. A total 112 volunteers between 18 70 years age participated study. The average participant 38 old, sample consisted 48 males 64 females. Five milliliters venous collected from participants' cubital vein GOT GPT determined. Participants then asked complete questionnaire addressing their meal, whether coffee consumed within 6 hours.Blood significantly higher than females (P < 0.001) due effects estrogen progesterone. Concentrations 0.01). There no other significant differences demonstrated.Understanding affect give new insight into mechanisms protect excess result better TBI.