Prepregnancy Low-Plasma Volume and Predisposition to Preeclampsia and Fetal Growth Restriction

• DOI: 10.1097/aog.0b013e318213cd31
• Publication Date: 2011-04-21T07:33:50Z
• Authors: Ralph R. Scholten; Simone Sep; Louis Peeters; Maria T. E. Hopman; Fred K. Lotgering; Marc E. A. Spaand...
• Keywords: Adult; Risk; NCEBP 14: Cardiovascular diseases IGMD 6: Hormonal regulation; Kaplan-Meier Estimate; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Pre-Eclampsia; Pregnancy; Recurrence; Odds Ratio; Humans; Plasma Volume; Proportional Hazards Models; Retrospective Studies; Fetal Growth Retardation; Infant, Newborn; 3. Good health; Logistic Models; Case-Control Studies; Multivariate Analysis; Premature Birth; Female; NCEBP 14: Cardiovascular diseases; NCEBP 14: Cardiovascular diseases IGMD 5: Health aging / healthy living

In Brief OBJECTIVE: To estimate whether recurrence risks of preeclampsia, preterm birth, and fetal growth restriction relate to prepregnancy plasma volume. METHODS: We conducted a retrospective cohort study in 580 formerly preeclamptic women control group. all we measured volume (iodine125-human serum albumin indicator dilution method) the nonpregnant state. One hundred seventy-eight normotensive (formerly preeclamptic) had subsequent pregnancy within period (1996–2008). Odds ratios (ORs) for recurrent small gestational age (SGA) neonates were estimated, using multivariable logistic regression with adjustment confounders. RESULTS: Plasma volumes lower who developed preeclampsia (1,241±158 mL/m2, 17% compared group) than without (1,335±167 11% group). Logistic analysis demonstrated that each 100-mL/m2 difference was associated an OR 0.6 (95% confidence interval [CI] 0.5–0.8) develop pregnancy. Risk delivery (before 37 weeks gestation) depended on pregnancy, adjusted hazard ratio birth 0.9 CI 0.7–1.1) change delivering SGA neonate independent preeclampsia. Each 0.8 0.5–0.9) deliver CONCLUSION: The risk relates inversely linearly LEVEL OF EVIDENCE: II