Co-occurrence of Cardiovascular and Prothrombotic Risk Factors in Women With a History of Preeclampsia

• DOI: 10.1097/aog.0b013e318273764b
• Publication Date: 2015-10-13T18:40:27Z
• Authors: Ralph R. Scholten; Maria T.E. Hopman; Fred C.G.J. Sweep; Maureen J. Van de...; Arie P. Van Dijk; Wim J. Oyen; Fred K. Lotgering; Marc E.A. Spaande...
• Keywords: Hyperhomocysteinemia; Gestational hypertension

Formerly preeclamptic women are at increased risk for remote cardiovascular and thrombotic diseases. We studied co-occurrence of prothrombotic factors within a cohort formerly tested if prevalence these profiles related to onset preeclampsia in previous pregnancy.We evaluated 1,297 nonpregnant (6-12 months postpartum) the presence four profiles: circulatory profile (hypertension or latent hypertension [low plasma volume, vascular resistance, both]; metabolic syndrome (World Health Organization criteria); thrombophilia (factor V Leiden, prothrombin mutation, protein C S deficiency); hyperhomocysteinemia. Trends between were using linear regression analysis.After exclusion 63 (4.9%) because incomplete data, 1,234 included. One more detected 958 (77.6%) women. Circulatory was prevalent (66.1%) than hyperhomocysteinemia (18.7%), (15.4%), (10.8%). Prevalence profile, syndrome, decreased significantly with gestational age delivery, whereas did not (P=.22). There minimal overlap (less 2%) thrombophilic hyperhomocysteinemia.Circulatory is present two thirds Metabolic thrombophilia, 10-20%. considerable other profiles, but among three profiles. factors, except decreases delivery preceding pregnancy.: II.