Tumor Necrosis Factor-α-Immunoreactive Cells in Nucleus Pulposus in Adolescent Patients With Lumbar Disc Herniation

• DOI: 10.1097/brs.0b013e3182739cb4
• Publication Date: 2012-09-18T09:06:55Z
• Authors: Seiji Ohtori; Gen Inoue; Yawara Eguchi; Sumihisa Orita; Masashi Takaso; Nobuyasu Ochiai; Shunji Kishida; Kazuki Kuniyoshi; Yasuchika Aoki; Junichi Nakamura; Tetsuhiro Ishikawa; Gen Arai; Masayuki Miyagi; Hiroto Kamoda; Miyako Suzuki; Yoshihiro Sakuma; Yasuhiro Oikawa; Gou Kubota; Kazuhide Inage; Takeshi Sainoh; Tomoaki Toyone; Kazuyo Yamauchi; Toshiaki Kotani; Tsutomu Akazawa; Shohei Minami; Kazuhisa Takahashi
• Keywords: Lumbar disc herniation; Back Pain; Radicular pain; Intervertebral Disc

Immunohistochemistry for tumor necrosis factor (TNF)-α in nucleus pulposus of adolescent patients with lumbar disc herniation.To examine whether an inflammatory cytokine is expressed the herniation.TNFα thought to play a crucial role radicular pain caused by herniation adult patients. However, expression TNFα has not been explored.Five samples from (age, 12-16 yr; n = 5) or controls requiring surgery other back problems 4; nonpainful scoliosis) were harvested during surgery. Nucleus specimens immunostained using antibodies and cells counted. We compared between 2 groups.In herniation, more TNFα-immunoreactive seen comparison scoliosis (P < 0.01).The results suggest that may herniation. The be related degeneration